Glucocorticoid Receptor Polymorphism A3669G Is Associated with Airflow Obstruction in Mild-to-Severe Asthma

Background: Glucocorticoids (GCs) represent the mainstay therapy for asthmatics. A subset of severe asthmatics fails to respond steroid-based therapies, leading important healthcare costs. Single nucleotide polymorphisms (SNPs) glucocorticoid receptor genes were associated with a response GC. We evaluate possible relation BclI and A3669G SNPs clinical, biological functional characteristics Methods: recruited 172 mild-to-severe asthmatic outpatients referring Severe Asthma Rare Lung Disease Unit at San Luigi University Hospital. Clinical data obtained recruitment when spirometry tests peripheral blood sampling performed. Patients genotyped through pyrosequencing assay results. Results: AG genotype younger, allergic had higher IgE levels compared AA (p < 0.05). Moreover, lower post-bronchodilator FEV1/FVC ratio than GG 0.05), RV/TLC Conclusions: The might be related type-2 asthma; in particular, allele SNP was GC our In conclusion, this observational cross-sectional study suggests role as predictor asthma severity phenotype.